Document Type
Patent
Patent Number
US Patent 4,303,419
Patent agency
United States Patent and Trademark Office
Publication Date
12-1-1981
Assignee
University of Iowa Research Foundation (Iowa City, IA, US)
Application Number
06/166,382
Date Filed
1980-07-07
Total Pages
6 pages
Abstract
N-nitrosamines are reacted with a denitrosating agent to cleave the N-NO bond and yield nitric oxide which may be analyzed to determine both qualitatively and quantitatively, the N-nitrosamine content of a test sample. The denitrosating reagent has the advantage of being useful, even in the presence of substantial amounts of water, and comprises a mixture of glacial acetic acid and a concentrated inorganic acid which is either phosphoric acid or sulfuric acid. The volume ratio of glacial acetic to concentrated acid is within the ratio of from 1:2 to 5:1. This acid component mixture is combined with from about 0.1% to about 5% by weight of soluble inorganic bromide or iodide salt.
Recommended Citation
Frank, Clyde W.; Nord, Paul J.; and Cox, Robert D. Method and composition for determination of N-nitrosamines. US Patent 4,303,419 filed July 07, 1980 and issued December 01, 1981. https://ir.uiowa.edu/patents/26
URL
https://ir.uiowa.edu/patents/26