Document Type

Patent

Patent Number

US Patent 6,201,168

Patent agency

United States Patent and Trademark Office

Publication Date

3-13-2001

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

09/378,418

Date Filed

1999-08-20

Total Pages

18 pages

Abstract

Disclosed is a mouse, cells derived therefrom, and methods for using the mouse, the mouse being homozygous for a disrupted δ-sarcoglycan gene, the disruption in the gene having been introduced into the mouse or an ancestor of the mouse at an embryonic stage. The disruption prevents the synthesis of functional δ-sarcoglycan in cells of the mouse and results in the mouse having a reduced amount of β- and ε-sarcoglycan and sarcospan, and a disruption of the sarcoglycan-sarcospan complex in smooth muscle of the mouse. Also disclosed is a mouse, cells derived therefrom, and methods for using the mouse, the mouse being homozygous for a disrupted β-sarcoglycan gene, the disruption in the gene having been introduced into the mouse or an ancestor of the mouse at an embryonic stage. The disruption prevents the synthesis of functional β-sarcoglycan in cells of the mouse and results in the mouse having a reduced amount of δ-and ε-sarcoglycan and sarcospan and α-dystroglycan in smooth muscle of the mouse.

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URL

https://ir.uiowa.edu/patents/262