US Patent 6,207,646
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical Group, Inc. (Wellesley, MA) ; The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed.
Krieg, Arthur M.; Kline, Joel; Klinman, Dennis; and Steinberg, Alfred D. Immunostimulatory nucleic acid molecules. US Patent 6,207,646 filed October 30, 1996 and issued March 27, 2001. https://ir.uiowa.edu/patents/267