Document Type

Patent

Patent Number

US Patent 6,207,878

Patent agency

United States Patent and Trademark Office

Publication Date

3-27-2001

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

09/422,762

Date Filed

1999-10-21

Total Pages

18 pages

Abstract

Disclosed is a transgenic knockout mouse whose genome has a homozygous disruption in its endogenous sarcospan gene, wherein the disruption prevents the synthesis of functional sarcospan in cells of the mouse. The mouse is characterized as exhibiting from 1.4 to 6.8 fold larger epididymal fat pad deposits as compared to the epididymal fat pad deposits of a wild type mouse. Methods for production of the mouse are presented. Also disclosed are cells derived from the transgenic knockout mouse. The mouse can be used in a method for identifying therapeutic agents for the treatment of an individual diagnosed with a metabolic disorder associated with a reduction or loss of expression of wild-type sarcospan. An example of such a disorder is weight gain in the individual associated with a reduction or loss of expression of wild-type sarcospan. These specific methods are also provided.

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URL

https://ir.uiowa.edu/patents/269