Document Type

Patent

Patent Number

US Patent 6,239,116

Patent agency

United States Patent and Trademark Office

Publication Date

5-29-2001

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical Group, Inc. (Wellesley, MA) ; The United States of America as represented by the Department of Health and Human Services (Washington, DC)

Application Number

08/960,774

Date Filed

1997-10-30

Total Pages

81 pages

Abstract

Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.

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URL

https://ir.uiowa.edu/patents/277