US Patent 6,239,116
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical Group, Inc. (Wellesley, MA) ; The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
Krieg, Arthur M. and Kline, Joel N. Immunostimulatory nucleic acid molecules. US Patent 6,239,116 filed October 30, 1997 and issued May 29, 2001. https://ir.uiowa.edu/patents/277