Document Type

Patent

Patent Number

US Patent 6,316,228

Patent agency

United States Patent and Trademark Office

Publication Date

11-13-2001

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

09/341,473

Date Filed

1999-07-12

Total Pages

7 pages

Abstract

Methods and compositions, including cell cultures, for producing nucleosides are provided which comprise contacting a nucleoside precursor and a sugar moiety donor with a cell containing a nucleoside phosphorylase. The nucleoside precursor can be a purine or pyrimidine base and the sugar moiety donor can comprise a ribose, a deoxyribose, including 2-deoxyribose, or other sugar of choice. The methods and composition can be used to make thymidine from thymine and 2-deoxyinosine or 2'-deoxyadenosine. Other nucleosides, including those having anticancer and/or antiviral properties, also can be obtained according to the invention.

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URL

https://ir.uiowa.edu/patents/291