US Patent 6,331,617
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
This invention relates to oligonucleotides with cationic phosphoramidate internucleoside linkages useful for binding to nucleic acid to inhibit or alter gene expression.
Weeks, Daniel L. and Dagle, John Positively charged oligonucleotides as regulators of gene expression. US Patent 6,331,617 filed March 27, 1998 and issued December 18, 2001. https://ir.uiowa.edu/patents/293