US Patent 6,352,834
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention includes a method for stimulating increased PSA production by prostate cancer cells, comprising the steps of reducing the amount of iron available to the prostate cancer cells; and causing increased PSA production. In another aspects of the present invention, there are provided prostate cancer diagnostic kits comprising a first container containing an iron chelator; and second container containing a free-PSA-specific antibody, wherein the free-PSA-specific antibody is detectable. Also provided as part of the present invention are methods for diagnosing prostate cancer in a human, comprising reducing the amount of available iron in the human, and subsequently testing PSA levels.
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Dreicer, Robert and Kemp, John Prostate cancer assays and related methods. US Patent 6,352,834 filed July 17, 1998 and issued March 05, 2002. https://ir.uiowa.edu/patents/295