US Patent 6,352,834
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention includes a method for stimulating increased PSA production by prostate cancer cells, comprising the steps of reducing the amount of iron available to the prostate cancer cells; and causing increased PSA production. In another aspects of the present invention, there are provided prostate cancer diagnostic kits comprising a first container containing an iron chelator; and second container containing a free-PSA-specific antibody, wherein the free-PSA-specific antibody is detectable. Also provided as part of the present invention are methods for diagnosing prostate cancer in a human, comprising reducing the amount of available iron in the human, and subsequently testing PSA levels.
Dreicer, Robert and Kemp, John Prostate cancer assays and related methods. US Patent 6,352,834 filed July 17, 1998 and issued March 05, 2002. https://ir.uiowa.edu/patents/295