Document Type

Patent

Patent Number

US Patent 6,365,337

Patent agency

United States Patent and Trademark Office

Publication Date

4-2-2002

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; The Jackson Laboratory (Bar Harbor, ME)

Application Number

09/123,030

Date Filed

1998-07-27

Total Pages

36 pages

Abstract

Disclosed are mammalian nucleic acid sequences encoding a neuronal-specific subunit of a voltage-gated calcium channel. Specifically disclosed are γ2, γ3 and γ4 subunits. In other aspects, the disclosure relates to expression vectors which encode neuronal-specific subunits, as well as cells containing such vectors. In other aspects, the disclosure relates to antigenic fusion proteins comprising at least a portion of a mammalian neuronal-specific subunit of a voltage-gated calcium channel. Such fusion proteins are useful, for example, in the production of antibodies specifically reactive with the subunits of the invention. The nucleic acid sequences of the invention find application, for example, in screening for compounds which modulate the activity of neuronal voltage-gated calcium channels and also in diagnostic methods for diagnosing the autoimmune disease Lambert-Eaton Syndrome, as well as diagnosing defects in γ subunit genes of a patient with a neuronal disease such as epilepsy. An additional application of the nucleic acid sequences of the invention is in therapeutic methods of treatment for such disorders.

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URL

https://ir.uiowa.edu/patents/298