US Patent 6,372,259
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A means and method for manufacturing palatable drug granules using a polymer having at least one free carboxyl group and PVP is described. This is achieved by (1) dissolving/suspending a drug in an aqueous solution of polymers and subsequently adjusting the pH of the solution to an acidic pH or (2) suspending a drug in an organic solution of one of the aforementioned polymers and then adding the other polymer solution, with constant agitation. The polymers form a complex and consequently entraps the drug and produce palatable drug granules that are suitable for preparing sustained release pharmaceutical dosage forms (powders, suspension, tablets, chewable tablets).
Kumar, Vijay Palatable, sustained release drug granules. US Patent 6,372,259 filed November 10, 1999 and issued April 16, 2002. https://ir.uiowa.edu/patents/299