Inventor

Vijay Kumar

Document Type

Patent

Patent Number

US Patent 6,372,259

Patent agency

United States Patent and Trademark Office

Publication Date

4-16-2002

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

09/437,449

Date Filed

1999-11-10

Total Pages

14 pages

Abstract

A means and method for manufacturing palatable drug granules using a polymer having at least one free carboxyl group and PVP is described. This is achieved by (1) dissolving/suspending a drug in an aqueous solution of polymers and subsequently adjusting the pH of the solution to an acidic pH or (2) suspending a drug in an organic solution of one of the aforementioned polymers and then adding the other polymer solution, with constant agitation. The polymers form a complex and consequently entraps the drug and produce palatable drug granules that are suitable for preparing sustained release pharmaceutical dosage forms (powders, suspension, tablets, chewable tablets).

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URL

https://ir.uiowa.edu/patents/299