US Patent 6,429,199
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention relates generally to methods and products for activating dendritic cells. In particular, the invention relates to oligonucleotides which have a specific sequence including at least one unmethylated CpG dinucleotide which are useful for activating dendritic cells. The methods are useful for in vitro, ex-vivo, and in vivo methods such as cancer immunotherapeutics, treatment of infectious disease and treatment of allergic disease.
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Krieg, Arthur M and Hartmann, Gunther Immunostimulatory nucleic acid molecules for activating dendritic cells. US Patent 6,429,199 filed November 13, 1998 and issued August 06, 2002. https://ir.uiowa.edu/patents/311