Document Type

Patent

Patent Number

US Patent 6,436,392

Patent agency

United States Patent and Trademark Office

Publication Date

8-20-2002

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

09/276,625

Date Filed

1999-03-25

Total Pages

80 pages

Abstract

The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.

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URL

https://ir.uiowa.edu/patents/312