US Patent 6,436,392
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
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Engelhardt, John F and Duan, Dongsheng Adeno-associated virus vectors. US Patent 6,436,392 filed March 25, 1999 and issued August 20, 2002. https://ir.uiowa.edu/patents/312