US Patent 6,479,504
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Georgia State University Research Foundation, Inc. (Atlanta, GA) ; The United States of America as represented by the Department of Veterans Affairs (Washington, DC)
The present invention relates generally to the field of immunology. More particularly it concerns compositions and methods for inhibiting stimulation of the immune system. The compounds and methods comprise compounds that are analogs and derivatives of chloroquine, such as 4-aminoquinolines, and other weak bases. They can be used in preventative and therapeutic treatments of autoimmune diseases and phenomena, transplant rejection such as host-versus-graft disease, and sepsis.
Macfarlane, Donald E.; Strekowski, Lucjan; Manzel, Lori; Ismail, Fyaz M. D.; and Barlin, Gordon B. Antagonism of immunostimulatory CpG-oligonucleotides by 4-aminoquinolines and other weak bases. US Patent 6,479,504 filed June 16, 2000 and issued November 12, 2002. https://ir.uiowa.edu/patents/317