US Patent 6,492,328
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; The Regents of the University of California (Oakland, CA, US)
Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and were well-tolerated in vivo after intravenous injection. Novispirins also bind lipopolysaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections.
Lehrer, Robert I.; Waring, Alan J.; and Tack, Brian F. Novispirins: antimicrobial peptides. US Patent 6,492,328 filed April 19, 2001 and issued December 10, 2002. https://ir.uiowa.edu/patents/318