Document Type

Patent

Patent Number

US Patent 6,492,328

Patent agency

United States Patent and Trademark Office

Publication Date

12-10-2002

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; The Regents of the University of California (Oakland, CA, US)

Application Number

09/840,009

Date Filed

2001-04-19

Total Pages

26 pages

Abstract

Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and were well-tolerated in vivo after intravenous injection. Novispirins also bind lipopolysaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections.

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URL

https://ir.uiowa.edu/patents/318