US Patent 6,518,037
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention discloses a mutant Neisseria having extensive membrane blebbing, both an indicium and a cause of virulence in the gonococcus and meningococcus. Methods are disclosed for making and characterizing the mutant, bmrRS. Methods are disclosed for isolating bmrRS membranes for use as a vaccine. Methods are also disclosed for the use of the mutant for determining the virulence of clinical samples of N. gonorrhoeae and N. meningitidis. Methods are also disclosed for the screening of antibiotics targeted to virulent Neisseria.
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Apicella, Michael A and Preston, Andrew Two-component system that controls bacterial membrane synthesis. US Patent 6,518,037 filed November 12, 1999 and issued February 11, 2003. https://ir.uiowa.edu/patents/321