Document Type

Patent

Patent Number

US Patent 6,518,037

Patent agency

United States Patent and Trademark Office

Publication Date

2-11-2003

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

09/439,226

Date Filed

1999-11-12

Total Pages

16 pages

Abstract

The present invention discloses a mutant Neisseria having extensive membrane blebbing, both an indicium and a cause of virulence in the gonococcus and meningococcus. Methods are disclosed for making and characterizing the mutant, bmrRS. Methods are disclosed for isolating bmrRS membranes for use as a vaccine. Methods are also disclosed for the use of the mutant for determining the virulence of clinical samples of N. gonorrhoeae and N. meningitidis. Methods are also disclosed for the screening of antibiotics targeted to virulent Neisseria.

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URL

https://ir.uiowa.edu/patents/321