US Patent 6,535,821
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention is directed towards a system and method for optimization of contrast enhancement utilizing a bolus propagation model, a computerized predictor of the bolus position, and a real-time tomographic imaging system with an adaptive mechanism to move a patient and/or the imaging components. The system and method can be applied to X-ray CT angiography that relies on bolus peak prediction, real-time CT observation and adaptive table translation. In particular, the discrepancy between the bolus location predicted by a bolus propagation model and the real-time CT measurement is reconciled via a computerized predictor such as a linear extrpolator or a Kalman filter and fed into an adaptive table transport system to drive the table to chase the contrast bolus accordingly.
Wang, Ge and Vannier, Michael W. System and method of bolus-chasing angiography with adaptive real-time computed tomography (CT). US Patent 6,535,821 filed February 09, 2001 and issued March 18, 2003. https://ir.uiowa.edu/patents/326