US Patent 6,566,061
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; The United States of America, as represented by the Department of Health and Human Services (Washington, DC, US)
Nucleic acid sequences within the q13 region of the X chromosome having polymorphisms associated with neuropsychiatric disorders and associated conditions are disclosed herein. One polymorphism occurs within the coding region of the HOPA gene and introduces a four amino acid insertion into a putative OPA domain, a domain which has been shown to be involved in tissue specific expression. Compositions including nucleic acids having these polymorphisms and antibodies to polymorphic regions within proteins encoded in the PCTG4 region are provided. Methods of using the information and nucleic acid sequences disclosed herein for the diagnosis and assessment of pathologies associated with neuropsychiatric disorders and associated conditions are also provided.
Philibert, Robert A.; Ginns, Edward I.; and Delisi, Lynn Identification of polymorphisms in the PCTG4 region of Xq13. US Patent 6,566,061 filed January 26, 2000 and issued May 20, 2003. https://ir.uiowa.edu/patents/328