US Patent 6,635,432
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
An assay for determining agonists, antagonists, or modulators for acid-sensing ion channels. The assay is especially useful for screening analgesics. The screening assay can be provided in a kit form. The assay comprises administering the composition to be screened to cells expressing acid-gated channels and then determining whether the composition inhibits, enhances, or has no effect on the channels when acid is introduced. The determination can be performed by analyzing whether a current is sustained by the cells in the presence of the composition and the acid. This current can be compared to that sustained by the FMRFamide and related peptides.
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Welsh, Michael J and Askwith, Candice C Peptide potentiation of acid-sensory ion channel in pain. US Patent 6,635,432 filed April 25, 2000 and issued October 21, 2003. https://ir.uiowa.edu/patents/340