US Patent 6,653,292
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
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Krieg, Arthur M and Weiher, George Method of treating cancer using immunostimulatory oligonucleotides. US Patent 6,653,292 filed June 21, 1999 and issued November 25, 2003. https://ir.uiowa.edu/patents/346