Document Type

Patent

Patent Number

US Patent 6,660,750

Patent agency

United States Patent and Trademark Office

Publication Date

12-9-2003

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; The United States of America, as represented by the Department of Health and Human Services (Washington, DC, US)

Application Number

09/784,633

Date Filed

2001-02-15

Total Pages

42 pages

Abstract

Disclosed is the unexpected discovery that flavopiridol binds tightly to the transcription elongation factor, P-TEFb and dramatically inhibits its activity. As P-TEFb is required for HIV propagation and replication, this invention provides new methods, compositions and kits for the effective treatment of HIV infections and AIDS using flavopiridol, both alone and combination with other therapies.

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URL

https://ir.uiowa.edu/patents/348