US Patent 6,660,750
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; The United States of America, as represented by the Department of Health and Human Services (Washington, DC, US)
Disclosed is the unexpected discovery that flavopiridol binds tightly to the transcription elongation factor, P-TEFb and dramatically inhibits its activity. As P-TEFb is required for HIV propagation and replication, this invention provides new methods, compositions and kits for the effective treatment of HIV infections and AIDS using flavopiridol, both alone and combination with other therapies.
Price, David H. and Senderowicz, Adrian M. Flavopiridol methods and compositions for HIV therapy. US Patent 6,660,750 filed February 15, 2001 and issued December 09, 2003. https://ir.uiowa.edu/patents/348