US Patent 6,716,819
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A method for killing infectious microbial cells by exposing the microbial cells to endogenous antimicrobial compounds. Activation of the antimicrobials is achieved by addition of low permeability, non-ionic osmolytes to lower ionic strength in body fluids where the antimicrobials have been previously suppressed by alteration of ionic transport (increase in salt concentration). The method can be used to treat cystic fibrosis. Cystic fibrosis causes elevated salt concentrations in the airway surface liquid (ASL) occur due to the impaired chloride transport across the epithelia. Xylitol has been found to be an effective low permeability, non-ionic osmolyte for use in the present invention.
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Welsh, Michael J and Zabner, Joseph Use of xylitol to reduce ionic strength and activate endogenous antimicrobials for prevention and treatment of infections. US Patent 6,716,819 filed May 21, 2001 and issued April 06, 2004. https://ir.uiowa.edu/patents/350