US Patent 6,720,151
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A gene previously identified in the context of controlling filamentous growth in C. albicans, TUP1, plays a central role in the regulation of phenotype switching in Candida cells. Accordingly, compounds and therapeutic protocols can be screened for an ability to disrupt the pathway, controlled by TUP1, that is comprised of genes the expression of which affect switching specifically. Agents thus identified are candidates for use in treating or preventing candidiasis.
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Soll, David R; Lockhart, Shawn R; and Zhao, Rui Therapeutic agents that inhibit the tup1 pathway. US Patent 6,720,151 filed September 10, 2002 and issued April 13, 2004. https://ir.uiowa.edu/patents/352