US Patent 6,723,321
United States Patent and Trademark Office
The Board of Trustees of the University of Illinois (Urbana, IL) ; University of Iowa Research Foundation (Iowa City, IA, US)
Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.
Greenberg, Peter E.; Cronan Jr., John E.; Plapp, Bryce V.; and Parsek, Matthew R. Autoinducer synthase modulating compounds and uses thereof. US Patent 6,723,321 filed January 06, 1999 and issued April 20, 2004. https://ir.uiowa.edu/patents/353