Document Type

Patent

Patent Number

US Patent 6,727,234

Patent agency

United States Patent and Trademark Office

Publication Date

4-27-2004

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

10/116,737

Date Filed

2002-04-03

Total Pages

17 pages

Abstract

The invention provides compounds of formula I: wherein X, R1, R2, and n have any of the values defined in the specification, and their pharmaceutically acceptable salts. The compounds are useful, for example, for blocking prenylation transferase enzymes, for probing or diagnosing protein prenylation processes, and for treating cancer in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and intermediates useful for the synthesis of compounds of formula I.

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URL

https://ir.uiowa.edu/patents/354