US Patent 6,809,181
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention relates a novel antimicrobial peptide HBD-3 and derivatives thereof as well as the gene encoding the peptide. The invention further relates to methods of use of the HBD-3 peptide including a method of inhibiting microbial growth by administering an effective amount of the HBD-3 peptide alone or in combinination with other antimicrobial agents or antibiotics. In addition, the immunomodulatory properties of the HBD-3 peptide also facilitate the manipulation of the immune response, i.e., as a chemoattractant for immature dentritic cells or memory T cells.
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McCray, Paul B Jr; Tack, Brian F; Jia, Hong Peng; and Schutte, Brian C Human beta-defensin-3 (HBD-3), a highly cationic beta-defensin antimicrobial peptide. US Patent 6,809,181 filed June 01, 2001 and issued October 26, 2004. https://ir.uiowa.edu/patents/363