US Patent 6,824,998
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention provides compounds useful for the detection of the enzyme tripeptidyl protease I (TPP-1). The invention also provides methods of making such compounds, methods of using such compounds, and kits and compositions containing such compounds. In one embodiment, Gly-L-Pro-L-Ser-1-anthraquinonylhydrazide, in combination with p-anisaldehyde, is used to detect TPP-1.
Davidson, Beverly L. and Wiemer, David Compounds and methods for detecting tripeptidyl protease I. US Patent 6,824,998 filed March 19, 2003 and issued November 30, 2004. https://ir.uiowa.edu/patents/366