US Patent 6,843,997
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention provides methods directed to detecting antibodies that specifically bind to a varicella zoster polypeptide, detecting the presence of a varicella zoster virus in an animal, diagnosing a disease caused by varicella zoster virus, and detecting a varicella zoster virus having a single nucleotide polymorphism in ORF68. The present invention also provides a vaccine composition, a method for producing a modified attenuated varicella zoster virus, isolated polynucleotides, and isolated polypeptides, and viruses.
Grose, Charles F. and Santos, Richard Variant varicella-zoster viruses and methods of use. US Patent 6,843,997 filed November 06, 2002 and issued January 18, 2005. https://ir.uiowa.edu/patents/369