US Patent 6,855,314
United States Patent and Trademark Office
The United States of America as represented by the Department of Health and Human Services (Washington, DC, US) ; University of Iowa Research Foundation (Iowa City, IA, US)
The present invention provides methods of delivering nucleic acids to specific regions, tissues and cell types of the CNS. More particularly the invention provides methods of delivering nucleic acids to cells of the CNS such as cerebellar cells and ependymal cells. The invention also provides methods of delivering nucleic acids to cells of the lung such as alveolar cells using AAV5 vectors and particles.
Chiorini, John A.; Kotin, Robert M.; Davidson, Beverly; and Zabner, Joseph AAV5 vector for transducing brain cells and lung cells. US Patent 6,855,314 filed March 22, 2000 and issued February 15, 2005. https://ir.uiowa.edu/patents/370