US Patent 6,855,513
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Vertex Pharmaceuticals (San Diego) LLC (San Diego, CA, US)
The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginosa. Novel indicator strains and vectors for engineering the strains for use in the method of the invention are also provided.
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Whiteley, Marvin; Lee, Kimberly M; Greenberg, Peter E; and Muh, Ute Quorum sensing signaling in bacteria. US Patent 6,855,513 filed September 01, 2000 and issued February 15, 2005. https://ir.uiowa.edu/patents/371