Document Type

Patent

Patent Number

US Patent 6,855,549

Patent agency

United States Patent and Trademark Office

Publication Date

2-15-2005

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; Chiron Corporation (Emeryville, CA, US)

Application Number

09/448,613

Date Filed

1999-11-22

Total Pages

48 pages

Abstract

The present invention involves methods and compositions for increasing the susceptibility of target cells to transduction by gene transfer vectors. Specifically, it is proposed that increasing intracellular permeability in epithelial tissue increases the percentage of input vector that will transduce that target tissue. Specific examples show that receptors for retrovirus are preferentially accessible on the basolateral surface of airway epithelia, and permeabilizing such tissues results in greater infection with retrovirus. This has important implications in gene therapy, for example, to treat cystic fibrosis with the CFTR gene.

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URL

https://ir.uiowa.edu/patents/372