US Patent 6,870,043
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
GB virus C (GBV-C or hepatitis G virus) is a recently described flavivirus that frequently leads to chronic viremia in humans. Although associated with acute post-transfusion hepatitis, it is not clear if GBV-C is pathogenic for humans. A full-length cDNA was constructed from the plasma of a person with chronic GBV-C viremia. Peripheral blood mononuclear cells (PBMCs) transfected with full-length RNA transcripts from this GBV-C clone resulted in viral replication, demonstrating an isolated infectious GBV-C nucleic acid molecule. In addition to composition involving an isolated infectious GBV-C nucleic acid molecule, the present invention concerns methods of inhibiting and treating HIV infections.
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Xiang, Jinhua; Wünschmann, Sabina; Schmidt, Warren; and Stapleton, Jack Full-length GB virus C (hepatitis G virus) RNA transcripts are infectious in primary CD4 positive T cells. US Patent 6,870,043 filed April 05, 2001 and issued March 22, 2005. https://ir.uiowa.edu/patents/373