Document Type

Patent

Patent Number

US Patent 6,870,043

Patent agency

United States Patent and Trademark Office

Publication Date

3-22-2005

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

09/828,498

Date Filed

2001-04-05

Total Pages

69 pages

Abstract

GB virus C (GBV-C or hepatitis G virus) is a recently described flavivirus that frequently leads to chronic viremia in humans. Although associated with acute post-transfusion hepatitis, it is not clear if GBV-C is pathogenic for humans. A full-length cDNA was constructed from the plasma of a person with chronic GBV-C viremia. Peripheral blood mononuclear cells (PBMCs) transfected with full-length RNA transcripts from this GBV-C clone resulted in viral replication, demonstrating an isolated infectious GBV-C nucleic acid molecule. In addition to composition involving an isolated infectious GBV-C nucleic acid molecule, the present invention concerns methods of inhibiting and treating HIV infections.

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URL

https://ir.uiowa.edu/patents/373