Document Type
Patent
Patent Number
US Patent 6,870,043
Patent agency
United States Patent and Trademark Office
Publication Date
3-22-2005
Assignee
University of Iowa Research Foundation (Iowa City, IA, US)
Application Number
09/828,498
Date Filed
2001-04-05
Total Pages
69 pages
Abstract
GB virus C (GBV-C or hepatitis G virus) is a recently described flavivirus that frequently leads to chronic viremia in humans. Although associated with acute post-transfusion hepatitis, it is not clear if GBV-C is pathogenic for humans. A full-length cDNA was constructed from the plasma of a person with chronic GBV-C viremia. Peripheral blood mononuclear cells (PBMCs) transfected with full-length RNA transcripts from this GBV-C clone resulted in viral replication, demonstrating an isolated infectious GBV-C nucleic acid molecule. In addition to composition involving an isolated infectious GBV-C nucleic acid molecule, the present invention concerns methods of inhibiting and treating HIV infections.
Recommended Citation
Xiang, Jinhua; Wünschmann, Sabina; Schmidt, Warren; and Stapleton, Jack Full-length GB virus C (hepatitis G virus) RNA transcripts are infectious in primary CD4 positive T cells. US Patent 6,870,043 filed April 05, 2001 and issued March 22, 2005. https://ir.uiowa.edu/patents/373
URL
https://ir.uiowa.edu/patents/373