US Patent 6,900,185
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention is directed to methods for inhibiting tumor cell growth, causing tumor regression or eliminating tumor cells in a mammal afflicted with a tumor by administering to a TRAIL-sensitive cell a vector having a DNA expression cassette containing a promoter and a DNA sequence encoding TRAIL, wherein the expression of TRAIL results in tumor inhibition, regression or elimination.
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Griffith, Thomas S and Ratliff, Timothy Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer. US Patent 6,900,185 filed April 12, 2000 and issued May 31, 2005. https://ir.uiowa.edu/patents/378