US Patent 4,483,872
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of a non-classical carbonic anhydrase inhibitor. The most preferred compound is methyl acetazolamide. The invention also relates to a method of topically treating glaucoma with eye drops of a non-classical carbonic anhydrase inhibitor to reduce intraocular pressure.
Barfknecht, Charles F. and Schoenwald, Ronald D. Non-classical topical treatment for glaucoma using n-substituted sulfonamides. US Patent 4,483,872 filed July 11, 1983 and issued November 20, 1984. https://ir.uiowa.edu/patents/38