Document Type

Patent

Patent Number

US Patent 6,949,520

Patent agency

United States Patent and Trademark Office

Publication Date

9-27-2005

Assignee

Coley Pharmaceutical Group, Inc. (Wellesley, MA, US) ; University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical GmbH (Langenfeld, DE)

Application Number

09/672,126

Date Filed

2000-09-27

Total Pages

89 pages

Abstract

Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-α treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.

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URL

https://ir.uiowa.edu/patents/385