US Patent 6,949,520
United States Patent and Trademark Office
Coley Pharmaceutical Group, Inc. (Wellesley, MA, US) ; University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical GmbH (Langenfeld, DE)
Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-α treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.
Hartmann, Gunther; Bratzler, Robert L.; and Krieg, Arthur M. Methods related to immunostimulatory nucleic acid-induced interferon. US Patent 6,949,520 filed September 27, 2000 and issued September 27, 2005. https://ir.uiowa.edu/patents/385