US Patent 6,988,446
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention provides a novel constitutive nitric oxide synthase (NOS) that utilizes both L-arginine and arginine-rich peptides, oligopeptides or proteins, e.g., bradykinin (BK), as substrates in the synthesis of nitric oxide (NO). Also provided are methods of controlling, regulating or modulating NO synthesis in a subject.
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Rosazza, John P N and Chen, Yijun Purified nitric oxide synthase. US Patent 6,988,446 filed June 24, 2004 and issued January 24, 2006. https://ir.uiowa.edu/patents/389