US Patent 7,071,293
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; The Regents of the University of California (Oakland, CA, US)
The present invention relates to the use of antimicrobial peptides in the inhibition of microbial growth and proliferation. Novel antimicrobial truncated peptides are disclosed which are based upon SMAP 29 and RCAP 18, but which contain a lesser number of amino acid residues yet still retain bactericidal activity. In addition, synthetic peptides based upon the SMAP 29 protein are disclosed which have fewer amino acid residues and include substitutions yet retain substantial activity. The invention also relates to a method of inhibiting microbial growth by administering an effective amount of a peptide in accordance with the invention, or by combining the peptides with other antimicrobial agents or antibiotics.
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Tack, Brian F; McCray, Paul B Jr; Welsh, Michael; Travis, Sue M; and Lehrer, Robert Alpha helical peptides with broad spectrum antimicrobial activity that are insensitive to salt. US Patent 7,071,293 filed August 18, 2000 and issued July 04, 2006. https://ir.uiowa.edu/patents/402