US Patent 7,194,124
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
In an embodiment, a method includes receiving a number of optical sections of different parts of an embryo over time along a Z-axis through differential interference contrast microscopy. The method also includes outlining a perimeter of the number of parts of the embryo within the number of optical sections. Additionally, the method includes generating a three-dimensional faceted image of the number of parts based on the outlined perimeter. The method includes reconstructing, separately, a four-dimensional image of a growth of the different parts of the embryo over time based on the three-dimensional facet image of the number of parts.
Soll, David R.; Voss, Edward R.; and Heid, Paul J. Reconstruction and motion analysis of an embryo. US Patent 7,194,124 filed April 09, 2003 and issued March 20, 2007. https://ir.uiowa.edu/patents/422