US Patent 7,223,741
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
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Krieg, Arthur M Immunostimulatory nucleic acid molecules. US Patent 7,223,741 filed July 14, 2003 and issued May 29, 2007. https://ir.uiowa.edu/patents/425