US Patent 4,598,064
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Blood substitute and blood plasma expanders comprising alpha-alpha cross-linked stroma-free hemoglobin, which is substantially free of hemoglobin derivatives modified at other sites. The hemoglobin composition is intramolecularly cross-linked between Lys 99 Alpha1 and Lys 99 Alpha2.
Walder, Joseph A. Alpha-alpha cross-linked hemoglobins. US Patent 4,598,064 filed June 27, 1984 and issued July 01, 1986. https://ir.uiowa.edu/patents/43