Document Type

Patent

Patent Number

US Patent 7,271,156

Patent agency

United States Patent and Trademark Office

Publication Date

9-18-2007

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical GmbH (Düsseldorf, DE)

Application Number

10/314,578

Date Filed

2002-12-09

Total Pages

275 pages

Abstract

The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.

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URL

https://ir.uiowa.edu/patents/438