US Patent 7,271,156
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical GmbH (Düsseldorf, DE)
The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.
Krieg, Arthur M.; Vollmer, Jörg; and Schetter, Christian Immunostimulatory nucleic acids. US Patent 7,271,156 filed December 09, 2002 and issued September 18, 2007. https://ir.uiowa.edu/patents/438