Inventor

Joseph A. Walder

Document Type

Patent

Patent Number

US Patent 4,600,531

Patent agency

United States Patent and Trademark Office

Publication Date

7-15-1986

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

06/713,348

Date Filed

1985-03-18

Total Pages

11 pages

Abstract

A high yield method of production of a cross-linked hemoglobin derivative suitable for use as a blood substitute and plasma expander which is cross-linked between Lys 99 Alpha1 and Lys 99 Alpha2 in high percentage by adding the cross-linker in the presence of an added polyanion which blocks competing reactions at other sites of the protein.

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URL

https://ir.uiowa.edu/patents/44