US Patent 7,339,046
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The present invention offers new therapies for treating Cystic Fibrosis (CF), that are based on novel DNA molecules and proteins encoded by the DNA molecules. The present invention features DNA molecules encoding CFTR having a partially deleted R domain. The partial deletions in the R domain are between residues 708 and 835 of the wild-type CFTR.
Welsh, Michael J.; Ostedgaard, Lynda S.; and Zabner, Joseph CFTR with a partially deleted R domain and uses thereof. US Patent 7,339,046 filed February 14, 2003 and issued March 04, 2008. https://ir.uiowa.edu/patents/449