Document Type

Patent

Patent Number

US Patent 7,442,798

Patent agency

United States Patent and Trademark Office

Publication Date

10-28-2008

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; University of Rochester (Rochester, NY, US) ; East Carolina University (Greenville, NC, US)

Application Number

10/844,037

Date Filed

2004-05-11

Total Pages

23 pages

Abstract

Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal (“PQS”) molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.

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URL

https://ir.uiowa.edu/patents/466