US Patent 7,442,798
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; University of Rochester (Rochester, NY, US) ; East Carolina University (Greenville, NC, US)
Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal (“PQS”) molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.
Pesci, Everett C.; Iglewski, Barbara H.; Milbank, Jared B. J.; Pearson, James P.; Kende, Andrew S.; and Greenberg, Everett P. Autoinducer molecules and uses therefor. US Patent 7,442,798 filed May 11, 2004 and issued October 28, 2008. https://ir.uiowa.edu/patents/466