Document Type

Patent

Patent Number

US Patent 7,460,895

Patent agency

United States Patent and Trademark Office

Publication Date

12-2-2008

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

11/042,817

Date Filed

2005-01-24

Total Pages

19 pages

Abstract

A method for generating a net analyte signal calibration model for use in detecting and/or quantifying the amount of an analyte in a test subject. The net analyte signal can be generated by providing a set of in vivo infrared spectra for a test subject during a period in which an analyte concentration is essentially constant; calculating an optimal subspace of spectra that at least substantially describes all non-analyte dependent spectral variance in the in vivo spectra; providing a pure component infrared spectrum for the analyte; and calculating a net analyte signal spectrum from a data set comprising the optimal subspace spectra and the pure analyte spectrum. The net analyte signal calibration model can be used, for example, in measuring the concentration of analyte in a test subject, and/or for evaluating the analytical significance of an in vivo multivariate calibration model.

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URL

https://ir.uiowa.edu/patents/467