US Patent 7,524,828
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
Krieg, Arthur M. and Kline, Joel N. Immunostimulatory nucleic acid molecules. US Patent 7,524,828 filed August 18, 2004 and issued April 28, 2009. https://ir.uiowa.edu/patents/480