US Patent 7,538,096
United States Patent and Trademark Office
The General Hospital Corporation (Boston, MA, US) ; University of Iowa Research Foundation (Iowa City, IA, US)
This invention provides a method for inhibiting or preventing the abnormal growth of cells, including transformed cells, by administering an effective amount of O-acylated heparin derivative. Abnormal growth of cells refers to cell growth independent of normal regulatory mechanism (e.g. loss of contact inhibition). This includes the abnormal growth of: (1) tumor cells (tumors); (2) benign and malignant cells of other proliferative disease in which aberrant cellular proliferation occurs; (3) aberrant smooth muscle cell proliferation, such as might occur following treatment for coronary atherosclerosis such as angioplasty or the insertion of a stent into an occluded vessel.
Hales, Charles A.; Garg, Hari G.; Yu, Lunyin; and Linhardt, Robert J. Treatment and prevention of abnormal cellular proliferation. US Patent 7,538,096 filed March 16, 2005 and issued May 26, 2009. https://ir.uiowa.edu/patents/483