Document Type

Patent

Patent Number

US Patent 7,538,096

Patent agency

United States Patent and Trademark Office

Publication Date

5-26-2009

Assignee

The General Hospital Corporation (Boston, MA, US) ; University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

11/082,213

Date Filed

2005-03-16

Total Pages

34 pages

Abstract

This invention provides a method for inhibiting or preventing the abnormal growth of cells, including transformed cells, by administering an effective amount of O-acylated heparin derivative. Abnormal growth of cells refers to cell growth independent of normal regulatory mechanism (e.g. loss of contact inhibition). This includes the abnormal growth of: (1) tumor cells (tumors); (2) benign and malignant cells of other proliferative disease in which aberrant cellular proliferation occurs; (3) aberrant smooth muscle cell proliferation, such as might occur following treatment for coronary atherosclerosis such as angioplasty or the insertion of a stent into an occluded vessel.

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URL

https://ir.uiowa.edu/patents/483