Document Type

Patent

Patent Number

US Patent 7,553,646

Patent agency

United States Patent and Trademark Office

Publication Date

6-30-2009

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

11/460,532

Date Filed

2006-07-27

Total Pages

18 pages

Abstract

The present invention provides novel methods for the synthesis of racemic and enantiomers of modafinil via microbial oxidation-amidation transformation. The methods include the successive oxidation-amidation of benzhydrylsulfanyl carboxylic acid to produce racemic and enantiomers of modafinil using at least one microorganism of yeast, bacteria, or fungus. Also disclosed are pharmaceutical compositions of racemic and enantiomers of modafinil along with their use in the treatment of diseases, including attention deficit hyperactivity disorder and drug addiction.

Share

COinS
 

URL

https://ir.uiowa.edu/patents/485