US Patent 7,649,089
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A new cellulose excipient, OCCAE, suitable for use as a binder, filler, and/or disintegrant in the development of solid dosage forms and as a bodying agent or a drug carrier in the preparation of topical formulations is described. The cellulose excipient is formed by reacting an oxidized cellulose ester with an alcohol in the presence of a catalyst. The invention also describes the formation of controlled release microspheres using OCCAE and/or oxidized cellulose esters that may be used to control the release of drug in a patient over a time period of several hours to several days.
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Kumar, Vijay and Dong, Yang Biodegradable oxidized cellulose esters and their uses as microspheres. US Patent 7,649,089 filed October 28, 2004 and issued January 19, 2010. https://ir.uiowa.edu/patents/494