US Patent 7,649,089
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A new cellulose excipient, OCCAE, suitable for use as a binder, filler, and/or disintegrant in the development of solid dosage forms and as a bodying agent or a drug carrier in the preparation of topical formulations is described. The cellulose excipient is formed by reacting an oxidized cellulose ester with an alcohol in the presence of a catalyst. The invention also describes the formation of controlled release microspheres using OCCAE and/or oxidized cellulose esters that may be used to control the release of drug in a patient over a time period of several hours to several days.
Kumar, Vijay and Dong, Yang Biodegradable oxidized cellulose esters and their uses as microspheres. US Patent 7,649,089 filed October 28, 2004 and issued January 19, 2010. https://ir.uiowa.edu/patents/494