US Patent 7,713,529
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Coley Pharmaceutical Group, Inc. (New York, NY, US) ; The United States of America as represented by the Department of Health and Human Services (Washington, DC, US)
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
Krieg, Arthur M.; Klinman, Dennis; and Steinberg, Alfred D. Methods for treating and preventing infectious disease. US Patent 7,713,529 filed November 27, 2002 and issued May 11, 2010. https://ir.uiowa.edu/patents/506