US Patent 7,741,469
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of genes encoding proteins involved in deafness caused by dominant negative mechanism of action by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of genes involved in deafness caused by dominant negative mechanism of action.
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Smith, Richard J Compositions for treating hearing loss and methods of use thereof. US Patent 7,741,469 filed April 04, 2007 and issued June 22, 2010. https://ir.uiowa.edu/patents/513